Effect of inhaled prostacyclin in combination with almitrine on ventilation-perfusion distributions in experimental lung injury.

@article{Dembinski2001EffectOI,
  title={Effect of inhaled prostacyclin in combination with almitrine on ventilation-perfusion distributions in experimental lung injury.},
  author={Rolf Dembinski and Martin H. Max and Fernando Guerrero L{\'o}pez and Ralf Kuhlen and Ralf R. Kurth and Rolf Rossaint},
  journal={Anesthesiology},
  year={2001},
  volume={94 3},
  pages={
          461-7
        }
}
BACKGROUND Inhaled prostacyclin and intravenous almitrine have both been shown to improve pulmonary gas exchange in acute lung injury (ALI). This study was performed to investigate a possible additive effect of prostacyclin and almitrine on pulmonary ventilation-perfusion (VA/Q) ratio in ALI compared with inhaled prostacyclin or intravenous almitrine alone. METHODS Experimental ALI was established in 24 pigs by repeated lung lavage. Animals were randomly assigned to receive either 25 ng.kg(-1… CONTINUE READING

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