Effect of ingestion of eicosapentaenoic acid ethyl ester on carrageenan-induced colitis in guinea pigs.

@article{Kitsukawa1992EffectOI,
  title={Effect of ingestion of eicosapentaenoic acid ethyl ester on carrageenan-induced colitis in guinea pigs.},
  author={Yukio Kitsukawa and Haruhiro Saito and Yoshio Suzuki and Junji Kasanuki and Yoshifuru Tamura and Shohei Yoshida},
  journal={Gastroenterology},
  year={1992},
  volume={102 6},
  pages={1859-66}
}
The effect of highly purified eicosapentaenoic acid ethyl ester (EPA-E) on colitis was investigated using a guinea pig model. The technique for preparing a degraded carrageenan with a molecular weight of about 30,000 from commercial iota-carrageenan was first refined. When this degraded carrageenan was fed to guinea pigs, localized ulcerations occurred in… CONTINUE READING