Effect of infliximab on sight-threatening panuveitis in Behcet's disease

  title={Effect of infliximab on sight-threatening panuveitis in Behcet's disease},
  author={P. Sfikakis and P. Theodossiadis and CG Katsiari and P. Kaklamanis and NN Markomichelakis},
  journal={The Lancet},
  • P. Sfikakis, P. Theodossiadis, +2 authors NN Markomichelakis
  • Published 2001
  • Medicine
  • The Lancet
  • Permanent loss of vision resulting from relapsing ocular inflammation occurs frequently in patients with Behçet's disease, despite intensive, chronic immunosuppressive therapy. Since tumour necrosis factor (TNF) might have an important pathogenetic role in Behçet's disease, we decided to give a single infusion of infliximab-a monoclonal antibody against TNF-to five patients with relapsing panuveitis, at the immediate onset of last relapse. Remission of ocular inflammation was evident within the… CONTINUE READING
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