Effect of induced synovial inflammation on pharmacokinetics and synovial concentration of sodium ampicillin and kanamycin sulfate after systemic administration in ponies.

@article{Firth1988EffectOI,
  title={Effect of induced synovial inflammation on pharmacokinetics and synovial concentration of sodium ampicillin and kanamycin sulfate after systemic administration in ponies.},
  author={Elwyn C. Firth and Wim R. Klein and J. F. M. Nouws and Theo Wensing},
  journal={Journal of veterinary pharmacology and therapeutics},
  year={1988},
  volume={11 1},
  pages={56-62}
}
Single doses of sodium ampicillin (10 mg/kg) and kanamycin sulfate (5 mg/kg) were administered intramuscularly (i.m.) separately, and then together, to five pony mares. The plasma antibiotic concentration-time curves were constructed. The pharmacokinetic parameters of the antibiotics given separately were not altered by concurrent administration. Four of the five pony mares were then given the i.m. kanamycin/ampicillin combination 4 h after acute synovitis and fever had been induced by… CONTINUE READING