Endocrine changes following induced abortion were studied in 86 women. The group included 34 women at 5-6 weeks of gestation and 52 at 8 weeks of gestation; 66% were in a 20-30 years old age group. All women were subjected to conventional dilatation and curettage; 34 underwent abortion without received anesthesia with sombrevin (8-10 mg/kg). Functional state of the endocrine system was evaluated by the changes in steroid hormone levels in the blood and catecholamine levels in the urine. Termination of pregnancy without anesthesia at both 5-6 and 8 weeks of gestation resulted in marked decrease in secretion of sex hormones. Within 3 hours after abortion, there was a 56-58% decrease in estradiol secretion, 27% decrease in progesterone secretion, 38% decrease in cortisol secretion and 35% decrease in corticosterone secretion. Testosterone levels did not differ from those before abortion. Abortion without anesthesia caused marked activation of the symathico-adrenal system seen as a 25-29% increase in the urinary excretion of adrenalin and noradrenalin. Abortion under sombrevin anesthesia produced similar decrease in secretion of sex hormones. At the same time, excretion of catecholamines showed marked decrease, compared with gradual increase following abortion on without anesthesia. It was concluded that sombrevin anesthesia reduces the postoperative stress of the adrenal system.