Effect of indomethacin on blood pressure lowering by captopril and losartan in hypertensive patients.

@article{Conlin2000EffectOI,
  title={Effect of indomethacin on blood pressure lowering by captopril and losartan in hypertensive patients.},
  author={Paul R. Conlin and T. J. M. Moore and Stephen L. Swartz and Ed Barr and Lisa P. Gazdick and Cindy Fletcher and Paul T Delucca and Laura Demopoulos},
  journal={Hypertension},
  year={2000},
  volume={36 3},
  pages={461-5}
}
NSAIDs are known to attenuate the effects of some antihypertensive medications. It is not known whether the new class of angiotensin II receptor antagonists is similarly affected. We conducted a multicenter study assessing the effect of indomethacin on the antihypertensive effects of losartan and captopril. After 4 weeks of placebo washout, hypertensive patients received 6 weeks of active antihypertensive therapy with either 50 mg losartan once daily (n=111) or 25 mg captopril twice daily for 1… CONTINUE READING
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