Effect of indole on adenylate energy charge and mitochondrial phosphorylative activity of rat liver.

1. Luminal perfusion of 5.0 mM indole (0.5 ml/min) in small intestine lowered hepatic adenylate energy charge [(ATP + ADP/2)/(ATP + ADP + AMP)] from 0.85 to 0.80. 2. Liver perfusion of indole (0.5, 5.0 mM) also lowered adenylate energy charge. 3. In liver perfusion experiments, both ketone body ratio (beta-hydroxybutyrate/acetoacetate) and oxygen… CONTINUE READING