Effect of increasing oral doses of loperamide on gallbladder motility in man.

@article{Hopman1990EffectOI,
  title={Effect of increasing oral doses of loperamide on gallbladder motility in man.},
  author={Wim P M Hopman and Gerd Rosenbusch and Jeroen J. Jansen and Cornelis B. H. W. Lamers},
  journal={British journal of clinical pharmacology},
  year={1990},
  volume={29 1},
  pages={55-60}
}
1. Loperamide, a peripherally acting opiate receptor agonist with antidiarrhoeal action, inhibits ileal and colonic motor function. To determine the effect of loperamide on gallbladder motility, we have pretreated five healthy volunteers with 2 mg oral loperamide 24 h, 20, 12 and 2.5 h before; six healthy volunteers with 16 mg oral loperamide 2.5 h before; and eight healthy volunteers with 16 mg oral loperamide 12 and 2.5 h before intravenous infusion of a 'physiological dose' of 12.5 pmol kg-1… CONTINUE READING

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