Effect of increasing estradiol levels on platelet peripheral benzodiazepine binding sites in women undergoing human menopausal gonadotropin treatment.

@article{Diorio1990EffectOI,
  title={Effect of increasing estradiol levels on platelet peripheral benzodiazepine binding sites in women undergoing human menopausal gonadotropin treatment.},
  author={D L Diorio and S. A. Welner and Togas Tulandi and Samarthji Lal and Barbara Suranyi-Cadotte},
  journal={Neuropsychobiology},
  year={1990},
  volume={23 4},
  pages={169-72}
}
The effect of increasing serum estradiol levels on platelet [3H]PK 11195 binding was investigated to determine the influence of gonadal steroids on platelet peripheral benzodiazepine binding sites. Serum estradiol and platelet [3H]PK 11195 binding were determined in 10 anovulatory, but otherwise healthy women before and after treatment with human menopausal gonadotropin. Despite a 30-fold increase in posttreatment estradiol, the kinetic parameters of platelet [3H]PK 11195 binding (Kd, Bmax… CONTINUE READING