Effect of increased brain serotonergic activity on endurance performance in the rat.

@article{Bailey1992EffectOI,
  title={Effect of increased brain serotonergic activity on endurance performance in the rat.},
  author={Stephen P. Bailey and John M Davis and E N Ahlborn},
  journal={Acta physiologica Scandinavica},
  year={1992},
  volume={145 1},
  pages={75-6}
}
Fatigue (the inability to maintain power output) during prolonged exercise has traditionally been attributed to inhibition of skeletal muscle contractile mechanisms. Recently, it has been hypothesized that fatigue during endurance exercise may be influenced by activity of the brain serotonergic system (Newsholme et al. 1987). More specifically, Newsholme et al. (1987) postulated that increasing levels of brain serotonin (5-HT) may result in feelings of lethargy and loss of drive which… CONTINUE READING