Effect of incorporation of cidofovir into DNA by human cytomegalovirus DNA polymerase on DNA elongation.

@article{Xiong1997EffectOI,
  title={Effect of incorporation of cidofovir into DNA by human cytomegalovirus DNA polymerase on DNA elongation.},
  author={Xiaoping Xiong and Jeffery L Smith and Ming Shuai Chen},
  journal={Antimicrobial agents and chemotherapy},
  year={1997},
  volume={41 3},
  pages={594-9}
}
Cidofovir (CDV) (HPMPC) has potent in vitro and in vivo activity against human cytomegalovirus (HCMV), CDV diphosphate (CDVpp), the putative antiviral metabolite of CDV, is an inhibitor and an alternate substrate of HCMV DNA polymerase. CDV is incorporated with the correct complementation to dGMP in the template, and the incorporated CDV at the primer end is not excised by the 3'-to-5' exonuclease activity of HCMV DNA polymerase. The incorporation of a CDV molecule causes a decrease in the rate… CONTINUE READING

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