Effect of in vivo treatment with rh GM-CSF on in vitro growth of haematopoietic progenitors in patients with myelodysplastic syndromes.

@article{Visani1992EffectOI,
  title={Effect of in vivo treatment with rh GM-CSF on in vitro growth of haematopoietic progenitors in patients with myelodysplastic syndromes.},
  author={Giuseppe Visani and Patrizia Tosi and Carlo Finelli and Barbara Gamberi and Giorgio Zauli and Annarita Cenacchi and M. Fogli and Roberto Colombini and Sante Tura},
  journal={Haematologica},
  year={1992},
  volume={77 2},
  pages={142-5}
}
BACKGROUND Recombinant (r) human (h) granulocyte/macrophage colony stimulating factor (rh GM-CSF) has been shown to increase the number of peripheral blood (PB) neutrophils, eosinophils and monocytes in myelodysplastic syndromes (MDS). The aims of this study were: 1) to evaluate the effect of rh GM-CSF therapy on the in vitro growth of granulocyte-erythroid-macrophage-megakaryocyte colonies (CFU-GEMM), erythroid colonies (BFU-E), and granulocyte-macrophage colonies (CFU-GM) in patients with MDS… CONTINUE READING