Effect of in vivo T-cell depletion on the effector T-cell function of immunity to Eimeria falciformis.

@article{Stiff1990EffectOI,
  title={Effect of in vivo T-cell depletion on the effector T-cell function of immunity to Eimeria falciformis.},
  author={Mary I. Stiff and John P. Vasilakos},
  journal={Infection and immunity},
  year={1990},
  volume={58 6},
  pages={
          1496-9
        }
}
BALB/c mice were exposed to the enteric parasite Eimeria falciformis to produce a natural acquired immunity. The mice were then depleted of their effector T-cell function by in vivo administration of a cytotoxic Thy-1.2 mouse monoclonal antibody. T-cell depletion was demonstrated by a reduction in concanavalin A-induced proliferation of splenic lymphocytes in treated mice compared with that in controls. Twenty-four hours following T-cell depletion, the mice were challenged with 5,000 oocysts of… CONTINUE READING