Effect of impurities on estradiol crystallization in a sustained-release implant.

Abstract

During the development of a silicone rubber implant for the delivery of estradiol 17-beta some batches of implants made from a certain lot of commercial estradiol inexplicably developed surface crystals of estradiol after several days of storage. An impurity profile was obtained for 28 lots of estradiol by a newly developed HPLC method. One or more… (More)

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@article{Needham1992EffectOI, title={Effect of impurities on estradiol crystallization in a sustained-release implant.}, author={Gregory F Needham and Roland Pfeiffer and G. L. Engel and Benjamin Rutherford and D. J. Allen}, journal={Journal of pharmaceutical sciences}, year={1992}, volume={81 10}, pages={1012-4} }