Effect of immunotoxins against Trypanosoma cruzi.

  title={Effect of immunotoxins against Trypanosoma cruzi.},
  author={Jaime M. Santana and Antonio R. L. Teixeira},
  journal={The American journal of tropical medicine and hygiene},
  volume={41 2},
Immunotoxins were constructed with IgG antibodies against Trypanosoma cruzi surface antigens by hybridization with abrin (ITA) and ricin (ITR) A chains. The biological activity of the hybrid macromolecules was tested on the parasite forms. Motility of parasite forms was lost in vitro after incubation with ITR. In general, killing of the parasite with ITR was more efficient than with ITA. Inhibition of protein synthesis after incubation with either ITR or ITA, measured by 3H-leucine… CONTINUE READING
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