Effect of immunosuppressive drugs on T and B lymphocytes in guinea pigs.

@article{Winkelstein1977EffectOI,
  title={Effect of immunosuppressive drugs on T and B lymphocytes in guinea pigs.},
  author={Asher Winkelstein},
  journal={Blood},
  year={1977},
  volume={50 1},
  pages={
          81-91
        }
}
Changes in the number of T and B lymphocytes were assessed in guinea pigs following administration of immunosuppressive drugs. I cells were measured by rosetting with papainized rabbit erythrocytes, B cells by complement rosettes. After a single intraperitoneal dose of cyclophosphamide (150 mg/kg), the number of T and B cells in both peripheral blood and lymph node suspensions decreased by 60%-70%. The reduction of both elements persisted through day 5 after drug administration. There was a… CONTINUE READING

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