Effect of immunomodulatory medication on regional gray matter loss in relapsing-remitting multiple sclerosis--a longitudinal MRI study.

@article{Bendfeldt2010EffectOI,
  title={Effect of immunomodulatory medication on regional gray matter loss in relapsing-remitting multiple sclerosis--a longitudinal MRI study.},
  author={Kerstin Bendfeldt and Hanspeter Egger and Thomas E. Nichols and Patrick Loetscher and Niklaus Denier and Pascal Kuster and Stefan Traud and Nicole Mueller-Lenke and Yvonne Naegelin and Achim Gass and Ludwig Kappos and Ernst-Wilhelm Radue and Stefan J. Borgwardt},
  journal={Brain research},
  year={2010},
  volume={1325},
  pages={174-82}
}
Prevention of global gray matter (GM) volume changes in multiple sclerosis (MS) are an objective in clinical trials, but the effect of immunomodulatory medication on regional GM atrophy progression is unclear. MRIs from 86 patients with relapsing-remitting MS (RRMS) followed up for 24 months were analyzed using voxel-based morphometry. An analysis of covariance model (cluster threshold, corrected p<0.05) was used to compare GM volumes between baseline and follow-up while stratified by… CONTINUE READING

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