Effect of imipramine on calcium and potassium currents in isolated bovine ventricular myocytes.

@article{Isenberg1985EffectOI,
  title={Effect of imipramine on calcium and potassium currents in isolated bovine ventricular myocytes.},
  author={Gerrit Isenberg and Juan Luis Tamargo},
  journal={European journal of pharmacology},
  year={1985},
  volume={108 2},
  pages={121-31}
}
Isolated bovine ventricular myocytes were investigated with a two-microelectrode voltage clamp technique. The clamp currents were analyzed in terms of ICa and IK. Possible effects on INa were avoided by superfusing the cells with a Na-free medium. Imipramine (IMI) was applied at a concentration of 3.6 microM. Within the initial 3 min (early phase), IMI reduced peak ICa by 38 +/- 9% but IMI did not change the time constants of inactivation, the voltage dependence of peak ICa or its reversal… CONTINUE READING
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