Effect of ifosfamide metabolites on sodium-dependent phosphate transport in a model of proximal tubular cells (LLC-PK1) in culture.

@article{Mohrmann1993EffectOI,
  title={Effect of ifosfamide metabolites on sodium-dependent phosphate transport in a model of proximal tubular cells (LLC-PK1) in culture.},
  author={Matthias Mohrmann and A. S.-L. Pauli and H M Walkenhorst and Barbara Sch{\"o}nfeld and Matthias Brandis},
  journal={Renal physiology and biochemistry},
  year={1993},
  volume={16 6},
  pages={285-98}
}
Ifosfamide (IF) is an alkylating cytostatic drug with urotoxic (hemorrhagic cystitis) and nephrotoxic side effects. Several cases of Fanconi syndrome in children following therapy with IF were reported. Little information is available concerning the pathomechanisms of transport inhibition by IF. We used a permanent renal epithelial cell line with proximal tubular characteristics (LLC-PK1) in order to investigate the effects of IF and some of its major metabolites (4-OH-IF, chloracetaldehyde… CONTINUE READING

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