Effect of hypoxia on the transcription pattern of subunit isoforms and the kinetics of cytochrome c oxidase in cortical astrocytes and cerebellar neurons.

@article{Horvat2006EffectOH,
  title={Effect of hypoxia on the transcription pattern of subunit isoforms and the kinetics of cytochrome c oxidase in cortical astrocytes and cerebellar neurons.},
  author={Susann Horvat and Cordian Beyer and Susanne Arnold},
  journal={Journal of neurochemistry},
  year={2006},
  volume={99 3},
  pages={937-51}
}
Brain energy metabolism essentially depends on the availability of oxygen representing the energetic substrate for cytochrome c oxidase (COX). The catalytic activity of mammalian COX is regulated by binding of ATP to the N-terminus of subunit IV. This causes an allosteric inhibition of the enzyme at a high energy level and thus plays an important role in adjusting energy production to cellular energy requirements. We have studied COX activity in cortical astrocytes and cerebellar granule cells… CONTINUE READING

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