Effect of hypoxia and reoxygenation on metabolic pathways in rat hepatocytes.

Abstract

BACKGROUND The mechanisms whereby rat hepatocytes undergo irreversible injury due to a lack of oxygen have not been established. METHODS Liver cells were used for reperfusion injury, and four compartmentalized pathways were evaluated during hypoxia (N2/CO2, 19:1) for 30 min followed by oxygen (O2/CO2, 19:1) for 30 min. RESULTS Cell viability decreased… (More)

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