Effect of hypoxia/reoxygenation on CD73 (ecto-5'-nucleotidase) in mouse microvessel endothelial cell lines.

@article{Li2006EffectOH,
  title={Effect of hypoxia/reoxygenation on CD73 (ecto-5'-nucleotidase) in mouse microvessel endothelial cell lines.},
  author={Xiaobo Li and Tingting Zhou and Xiuling Zhi and Fengdi Zhao and Lianhua Yin and Ping Zhou},
  journal={Microvascular research},
  year={2006},
  volume={72 1-2},
  pages={48-53}
}
Cerebral ischemia and post-ischemic reperfusion commonly result in significant brain damage. Brain microvessel endothelial cells, the key target cells and regulating sites, can secrete adenosine which plays an important neuroprotective role in the ischemic brain. A primary determinant of localized production of adenosine at tissue interfaces is ecto-5'-nucleotidase (CD73). In our experiments, we used bEnd.3 cells, immortalized mouse brain microvessel endothelial cell lines, as the target cells… CONTINUE READING

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