Effect of hypotonicity on cyclic adenosine monophosphate formation and action in vasopressin target cells.

@article{Eggena1975EffectOH,
  title={Effect of hypotonicity on cyclic adenosine monophosphate formation and action in vasopressin target cells.},
  author={Patrick Eggena and John I Christakis and L M Deppisch},
  journal={Kidney international},
  year={1975},
  volume={7 3},
  pages={161-9}
}
We have shown previously that overhydration of toads renders their urinary bladders less responsive to the antidiuretic action of vasopressin (AVP). The present study investigates the relationship between osmotic swelling of vasopressin target cells and their sensitivity to AVP and dibutyryl cyclic adenosine monophosphate (db-cAMP). Conditions which engender osmotic swelling of toad bladder epithelial cells, such as immersing bladders on both surfaces in hypotonic Ringer's fluid or subjecting… CONTINUE READING