Effect of hypothermia and delayed thrombolysis in a rat embolic stroke model.

@article{Meden1994EffectOH,
  title={Effect of hypothermia and delayed thrombolysis in a rat embolic stroke model.},
  author={Per Meden and Karsten Overgaard and Hans Pedersen and Gudrun Boysen},
  journal={Acta neurologica Scandinavica},
  year={1994},
  volume={90 2},
  pages={91-8}
}
Effect of hypothermia on cerebral infarcts was studied in rats embolized in the right carotid territory. Thirty-four served as normothermic controls receiving saline infusion only. In 16 rats hypothermia of 32 degrees C was induced by cooling with a fan, followed by embolization. The rats were kept hypothermic for the following 3 h before body temperature was raised to 37 degrees C. In 26 rats, treatment with human recombinant tissue plasminogen activator (20 mg/kg i.v. during 45 min), started… CONTINUE READING
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