Effect of hyperglycemia and neuropeptides on interleukin-8 expression and angiogenesis in dermal microvascular endothelial cells.

@article{Jain2011EffectOH,
  title={Effect of hyperglycemia and neuropeptides on interleukin-8 expression and angiogenesis in dermal microvascular endothelial cells.},
  author={Monica Jain and Frank W. Logerfo and Patrick J. Guthrie and Leena Pradhan},
  journal={Journal of vascular surgery},
  year={2011},
  volume={53 6},
  pages={1654-60.e2}
}
BACKGROUND Impaired wound healing is a major complication associated with diabetes, involving a dysregulation and impairments in the inflammatory and angiogenic phases of wound healing. Here, we examine the effects of the neuropeptides substance P (SP) and neuropeptide Y (NPY) on dermal microvascular endothelial cell (DMVEC) angiogenesis and interleukin-8 (IL-8) expression, a known effector of the neuropeptide pathways in normal and hyperglycemic conditions in vitro. METHODS DMVECs are… CONTINUE READING