Effect of hypercholesterolemia on expression and function of vascular soluble guanylyl cyclase.

@article{Laber2002EffectOH,
  title={Effect of hypercholesterolemia on expression and function of vascular soluble guanylyl cyclase.},
  author={Ute Laber and Thorsten Kober and Verena Schmitz and Astrid Schrammel and Wilfried Meyer and B Mayer and Martina Totzauer and Georg Kojda},
  journal={Circulation},
  year={2002},
  volume={105 7},
  pages={
          855-60
        }
}
BACKGROUND Vasorelaxation to endothelial NO is mediated by activation of soluble guanylyl cyclase (sGC) and impaired by hypercholesterolemia in animals and humans. We investigated whether hypercholesterolemia impacts expression and function of sGC. METHODS AND RESULTS White New Zealand rabbits (n=10 per group) received a standard diet for 16 weeks (SD16) (n=20) or 32 weeks (SD32) and a cholesterol diet (7.5 g/kg) for 16 weeks (CD16) (n=20) or 32 weeks (CD32), respectively. Another group… CONTINUE READING
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