Effect of hydroxyurea on the frequency of painful crises in sickle cell anemia. Investigators of the Multicenter Study of Hydroxyurea in Sickle Cell Anemia.

@article{Charache1995EffectOH,
  title={Effect of hydroxyurea on the frequency of painful crises in sickle cell anemia. Investigators of the Multicenter Study of Hydroxyurea in Sickle Cell Anemia.},
  author={Samuel Charache and Michael L Terrin and Richard Moore and George J. Dover and Franca Benedicty Barton and Sven Eckert and Robert Patrick McMahon and Duane Robina Bonds},
  journal={The New England journal of medicine},
  year={1995},
  volume={332 20},
  pages={1317-22}
}
BACKGROUND In a previous open-label study of hydroxyurea therapy, the synthesis of fetal hemoglobin increased in most patients with sickle cell anemia, with only mild myelotoxicity. By inhibiting sickling, increased levels of fetal hemoglobin might decrease the frequency of painful crises. METHODS In a double-blind, randomized clinical trial, we tested the efficacy of hydroxyurea in reducing the frequency of painful crises in adults with a history of three or more such crises per year. The… CONTINUE READING
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