Effect of hydroxyurea and dideoxyinosine on intracellular 3'-deoxyadenosine-5'-triphosphate concentrations in HIV-infected patients.

@article{Bakshi2007EffectOH,
  title={Effect of hydroxyurea and dideoxyinosine on intracellular 3'-deoxyadenosine-5'-triphosphate concentrations in HIV-infected patients.},
  author={Rahul P Bakshi and Fayez Hamzeh and Ian S. Frank and Joseph J Eron and Ronald J. Bosch and Susan L. Rosenkranz and Yoninah S Cramer and Michael A. Ussery and Charles Flexner},
  journal={AIDS research and human retroviruses},
  year={2007},
  volume={23 11},
  pages={1360-5}
}
Hydroxyurea (HU) significantly enhances the antiretroviral effects of the adenosine analog reverse transcriptase inhibitor dideoxyinosine (ddI). This is believed to be due to a reduction in intracellular de-oxyadenosine triphosphate (dATP) concentrations resulting from HU-mediated inhibition of ribonucleotide reductase (RnR). The effect of combined HU-ddI… CONTINUE READING