Effect of hydrophilicity and agmatine modification on degradation of poly(propylene fumarate-co-ethylene glycol) hydrogels.

@article{Tanahashi2003EffectOH,
  title={Effect of hydrophilicity and agmatine modification on degradation of poly(propylene fumarate-co-ethylene glycol) hydrogels.},
  author={Kazuhiro Tanahashi and Antonios G Mikos},
  journal={Journal of biomedical materials research. Part A},
  year={2003},
  volume={67 4},
  pages={1148-54}
}
We synthesized positively charged biodegradable hydrogels with different poly(propylene fumarate-co-ethylene glycol) [P(PF-co-EG)] block copolymers and agmatine-modified poly(ethylene glycol)-tethered fumarate [Agm-PEGF] by radical crosslinking and investigated the effect of copolymer composition and agmatine modification on their degradation. Hydrogels were incubated in phosphate-buffered saline (PBS) at 37 degrees C with periodic PBS changes. All hydrogels experienced a slight mass loss over… CONTINUE READING