Effect of hydrophilic polymers on the release of diltiazem hydrochloride from elementary osmotic pumps.

@article{Prabakaran2003EffectOH,
  title={Effect of hydrophilic polymers on the release of diltiazem hydrochloride from elementary osmotic pumps.},
  author={Dr. N. Prabakaran and Paramjit Singh and Parijat Kanaujia and Suresh Prasad Vyas},
  journal={International journal of pharmaceutics},
  year={2003},
  volume={259 1-2},
  pages={173-9}
}
Diltiazem hydrochloride (DLTZ) is a freely water-soluble drug, because of its higher aqueous solubility, the suitability of the drug with elementary osmotic pumps is restricted. Plain DLTZ elementary osmotic pump had shown higher release rate. Drug entrapment in polymer matrix or addition of release retardant materials (various polymers) can reduce the release rate of drug. In present study, effect of appropriate hydrophilic polymers (HP) on the release pattern was investigated. Ingredients of… CONTINUE READING

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