Effect of hydrogen sulfide in a porcine model of myocardial ischemia-reperfusion: comparison of different administration regimens and characterization of the cellular mechanisms of protection.

@article{Osipov2009EffectOH,
  title={Effect of hydrogen sulfide in a porcine model of myocardial ischemia-reperfusion: comparison of different administration regimens and characterization of the cellular mechanisms of protection.},
  author={Robert M Osipov and Michael P. Robich and Jun Feng and Yuhong Liu and Richard T. Clements and Hilary P Glazer and Neel R. Sodha and Csaba Szab{\'o} and Cesario F Bianchi and Frank W Sellke},
  journal={Journal of cardiovascular pharmacology},
  year={2009},
  volume={54 4},
  pages={
          287-97
        }
}
OBJECTIVE We investigate the impact of different regimens of parenteral hydrogen sulfide (H2S) administration on myocardium during ischemia-reperfusion (IR) and the molecular pathways involved in its cytoprotective effects. METHODS Eighteen male Yorkshire pigs underwent 60 minutes of mid-left anterior descending coronary artery occlusion followed by 120 minutes of reperfusion. Pigs received either placebo (control, n = 6) or H2S as a bolus (bolus group, n = 6, 0.2 mg/kg over 10 seconds at the… CONTINUE READING

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