Effect of hycanthone on Schistosoma mansoni macromolecular synthesis in vitro.

@article{Mattoccia1981EffectOH,
  title={Effect of hycanthone on Schistosoma mansoni macromolecular synthesis in vitro.},
  author={L. P. Mattoccia and A. Lelli and D. Cioli},
  journal={Molecular and biochemical parasitology},
  year={1981},
  volume={2 5-6},
  pages={
          295-307
        }
}
Adult, immature and hycanthone-resistant schistosomes were allowed to incorporate tritiated precursors of macromolecule synthesis in vitro, either in the presence of various concentrations of hycanthone, or at various times after removal of the drug. The effect on worms was compared to that on HeLa cells. The results show that hycanthone markedly inhibited the incorporation of uridine in all the systems studied, while the incorporation of thymidine and leucine was only secondarily affected. The… Expand
Binding of oxamniquine to the DNA of schistosomes.
Drug resistance in schistosomes.
Enzymes of uridine 5'-monophosphate biosynthesis in Schistosoma mansoni.
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