Effect of human serum albumin on transplacental transfer of glyburide.

@article{Nanovskaya2006EffectOH,
  title={Effect of human serum albumin on transplacental transfer of glyburide.},
  author={Tatiana N Nanovskaya and Ilona A Nekhayeva and Gary D. V. Hankins and Mahmoud S. Ahmed},
  journal={Biochemical pharmacology},
  year={2006},
  volume={72 5},
  pages={632-9}
}
Glyburide is a second-generation sulfonylurea hypoglycemic drug used for the treatment of select women with pregestational and gestational diabetes mellitus (GDM). In vitro and in vivo investigations demonstrated its very low transplacental transfer to the fetal circulation. However, the factors influencing its low transfer across the human placenta remain unclear. Therefore, the goal of the current investigation was to determine the effect of human serum albumin (HSA) on the transfer and… CONTINUE READING