Effect of human platelet supernatant on proliferation and matrix synthesis of human articular chondrocytes in monolayer and three-dimensional alginate cultures.

@article{Gaissmaier2005EffectOH,
  title={Effect of human platelet supernatant on proliferation and matrix synthesis of human articular chondrocytes in monolayer and three-dimensional alginate cultures.},
  author={Christoph Gaissmaier and J{\"u}rgen Fritz and Tilmann Krackhardt and Ingo Flesch and Wilhelm K Aicher and Nureddin Ashammakhi},
  journal={Biomaterials},
  year={2005},
  volume={26 14},
  pages={1953-60}
}
Articular cartilage is rich in collagen type II fibres and proteoglycans and is characterized by low cell density. Chondrocytes have specific nutritional requirements and therefore cannot be expanded in vitro without the risk of generating fibroblastoid cells expressing type I collagen. Therefore, various growth conditions were tested for cartilage tissue engineering. Human platelets are a rich source of many growth factors including transforming growth factor-beta and platelet-derived growth… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 47 extracted citations

Similar Papers

Loading similar papers…