Effect of human leukocyte antigen heterozygosity on infectious disease outcome: The need for allele-specific measures

@article{Lipsitch2002EffectOH,
  title={Effect of human leukocyte antigen heterozygosity on infectious disease outcome: The need for allele-specific measures},
  author={Marc Lipsitch and Carl T. Bergstrom and Rustom Antia},
  journal={BMC Medical Genetics},
  year={2002},
  volume={4},
  pages={2 - 2}
}
Doherty and Zinkernagel, who discovered that antigen presentation is restricted by the major histocompatibility complex (MHC, called HLA in humans), hypothesized that individuals heterozygous at particular MHC loci might be more resistant to particular infectious diseases than the corresponding homozygotes because heterozygotes could present a wider repertoire of antigens. The superiority of heterozygotes over either corresponding homozygote, which we term allele-specific overdominance, is of… CONTINUE READING