Effect of human dietary exposure levels of genistein during gestation and lactation on long-term reproductive development and sperm quality in mice.

@article{Fielden2003EffectOH,
  title={Effect of human dietary exposure levels of genistein during gestation and lactation on long-term reproductive development and sperm quality in mice.},
  author={M. R. Fielden and Sahar Samy and Kuo Chen Chou and Timothy R. Zacharewski},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  year={2003},
  volume={41 4},
  pages={447-54}
}
The objective of the present study was to determine the long-term reproductive effects of gestational and lactational exposure (0, 0.1, 0.5, 2.5 and 10 mg/kg/day) to genistein on male mice at levels comparable to or greater than human dietary exposures. Testicular growth, sperm count and motility, and sperm fertilizing ability in vitro was assessed in male offspring on postnatal days (PND) 105 and 315. Selected genes were also examined by real-time PCR to determine whether genistein caused… CONTINUE READING