Effect of human cerebrospinal fluid sampling frequency on amyloid-β levels.


BACKGROUND β-amyloid peptide (Aβ) is associated with neurodegeneration in Alzheimer's disease. Emerging evidence indicates that Aβ levels in cerebrospinal fluid (CSF) may serve as an early clinical biomarker for evaluating pharmacological activity of new drug candidates targeting Aβ production or Aβ clearance. Therefore, it is critical to understand whether… (More)
DOI: 10.1016/j.jalz.2011.05.900


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