Effect of high-intensity training on exercise-induced gene expression specific to ion homeostasis and metabolism.
@article{Nordsborg2003EffectOH,
title={Effect of high-intensity training on exercise-induced gene expression specific to ion homeostasis and metabolism.},
author={Nikolai Baastrup Nordsborg and Jens Bangsbo and Henriette Pilegaard},
journal={Journal of applied physiology},
year={2003},
volume={95 3},
pages={
1201-6
}
}Changes in gene expression during recovery from high-intensity, intermittent, one-legged exercise were studied before and after 5.5 wk of training. Genes related to metabolism, as well as Na+, K+, and pH homeostasis, were selected for analyses. After the same work was performed before and after the training period, several muscle biopsies were obtained from vastus lateralis muscle. In the untrained state, the Na+-K+-ATPase alpha1-subunit mRNA level was approximately threefold higher (P < 0.01…
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References
SHOWING 1-10 OF 47 REFERENCES
Transcriptional regulation of gene expression in human skeletal muscle during recovery from exercise.
- BiologyAmerican journal of physiology. Endocrinology and metabolism
- 2000
It is demonstrated that exercise induces transient increases in transcription of metabolic genes in human skeletal muscle, and the findings suggest that the cumulative effects of transient rises in transcription during recovery from consecutive bouts of exercise may represent the underlying kinetic basis for the cellular adaptations associated with exercise training.
Molecular adaptations in human skeletal muscle to endurance training under simulated hypoxic conditions.
- BiologyJournal of applied physiology
- 2001
The findings suggest that HIF-1 is specifically involved in the regulation of muscle adaptations after hypoxia training, and fine-tuning of the training response is recognized at the molecular level, and with less sensitivity also at the structural level, but not at global functional responses like maximal O(2) uptake or maximal power output.
Exercise induces a transient increase in transcription of the GLUT-4 gene in skeletal muscle.
- BiologyThe American journal of physiology
- 1993
It is proposed that the increase in GLut-4 mRNA evident with extended periods of training may result from a shift to pretranslational control and is the cumulative effect of repeated postexercise transient increases in GLUT-4 gene transcription.
Anaerobic muscle enzyme changes after interval training.
- BiologyInternational journal of sports medicine
- 1982
It is concluded that interval training with high intensity and a 1:4 work-rest ratio leads to increased activities of key enzymes involved in glycogenolysis and anaerobic glycolysis of skeletal muscle.
Influence of pre‐exercise muscle glycogen content on exercise‐induced transcriptional regulation of metabolic genes
- BiologyThe Journal of physiology
- 2002
Low muscle glycogen content enhances the transcriptional activation of some metabolic genes in response to exercise, raising the possibility that signalling mechanisms sensitive to glycogencontent and/or FFA availability may be linked to the transcriptionAL control of exercise‐responsive genes.
Effect of high-intensity exercise training on lactate/H+ transport capacity in human skeletal muscle.
- BiologyAmerican journal of physiology. Endocrinology and metabolism
- 1999
The present data show that intense exercise training can increase lactate/H+transport capacity in human skeletal muscle as well as improve the ability of the muscle to release lactate and H+ during contractions.
Muscle glycogen synthesis in recovery from intense exercise in humans.
- BiologyThe American journal of physiology
- 1997
Apparently, muscle glyconeogenesis may occur in humans, but the role of lactate as a substrate is minor and blood glucose appears to be the most important precursor for muscle glycogen synthesis after intense exercise.
Pre- and posttranslational upregulation of muscle-specific glycogen synthase in athletes.
- BiologyThe American journal of physiology
- 1994
It is concluded that athletes have increased whole body insulin-stimulated nonoxidative glucose metabolism associated with both pretranslational and posttranslational upregulation of muscle-specific glycogen synthase and phosphofructokinase.
Regulation of hexokinase II activity and expression in human muscle by moderate exercise.
- Biology, MedicineThe American journal of physiology
- 1998
The increase in HK II activity after moderate exercise in healthy subjects could be one factor responsible for the enhanced rate of insulin-stimulated glucose uptake seen after exercise.
Enzyme adaptations of human skeletal muscle during bicycle short-sprint training and detraining.
- BiologyActa physiologica Scandinavica
- 1997
A high level in supramaximal power output is suggested as a result of a muscle glycogenolytic and glycolytic adaptation, which may contribute to a rapid return to competitive fitness for sprinters and power athletes.




