Effect of high hydrostatic pressure on the bacterial mechanosensitive channel MscS

@article{Macdonald2005EffectOH,
  title={Effect of high hydrostatic pressure on the bacterial mechanosensitive channel MscS},
  author={Alister G. Macdonald and Boris Martinac},
  journal={European Biophysics Journal},
  year={2005},
  volume={34},
  pages={434-441}
}
We have investigated the effect of high hydrostatic pressure on MscS, the bacterial mechanosensitive channel of small conductance. Pressure affected channel kinetics but not conductance. At negative pipette voltages (corresponding to membrane depolarization in the inside-out patch configuration used in our experiments) the channel exhibited a reversible reduction in activity with increasing hydrostatic pressure between 0 and 900 atm (90 MPa) at 23°C. The reduced activity was characterized by a… CONTINUE READING

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