Effect of high-dose methylprednisolone administration on immune functions in multiple sclerosis patients.

@article{Wandinger1998EffectOH,
  title={Effect of high-dose methylprednisolone administration on immune functions in multiple sclerosis patients.},
  author={K. P. Wandinger and Karl Wessel and Peter Trillenberg and N Heindl and Holger Kirchner},
  journal={Acta neurologica Scandinavica},
  year={1998},
  volume={97 6},
  pages={359-65}
}
OBJECTIVES To investigate the in vivo effect of corticosteroid pulse therapy on immunocompetent cells in 18 patients given methylprednisolone to treat an acute episode of MS. MATERIAL AND METHODS Blood was sampled before and after 3 days of methylprednisolone administration at doses of 1 g/day. Lymphocyte subtyping was performed and whole blood cell cultures were used to measure the cytokine producing capacity for interleukin-1 (IL-1), interleukin-2 (IL-2), interferon-gamma (IFN-gamma), tumor… CONTINUE READING
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