Effect of high altitude and in vivo adenosine/(&bgr;)-adrenergic receptor blockade on ATP and 2,3BPG concentrations in red blood cells of avian embryos

@article{Dragon1999EffectOH,
  title={Effect of high altitude and in vivo adenosine/(&bgr;)-adrenergic receptor blockade on ATP and 2,3BPG concentrations in red blood cells of avian embryos},
  author={Dragon and R M Carey and Erica Martin and Theol Klaus Baumann},
  journal={The Journal of experimental biology},
  year={1999},
  volume={202 (Pt 20)},
  pages={
          2787-95
        }
}
In chick embryos, developmental changes of the blood oxygen tension control hemoglobin (Hb) oxygen affinity via modulation of ATP and 2, 3BPG concentrations in red blood cells. Hypoxia, which is a normal developmental condition for late chick embryos, causes a decrease of the red cell ATP concentration (and increase of red cell oxygen affinity) as well as activation of 2,3BPG synthesis via cyclic AMP-dependent signaling. Adenosine and catecholamines have been implicated as signaling substances… CONTINUE READING
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