Effect of heptaminol AMP amidate, a new nucleotide derivative, on in vitro humoral immunity.

@article{Saha1988EffectOH,
  title={Effect of heptaminol AMP amidate, a new nucleotide derivative, on in vitro humoral immunity.},
  author={A. Saha and K. Ueno and S. Ohmori and T. Igarashi and H. Kitagawa},
  journal={Japanese journal of pharmacology},
  year={1988},
  volume={47 1},
  pages={
          63-9
        }
}
Heptaminol AMP amidate (HAA), a newly developed derivative of 5'-AMP, was found to potentiate the in vitro primary humoral immune response against T cell-dependent antigen, sheep red blood cells, when HAA was present in the early phase of spleen cell culture. Such a potentiating effect was not found against T cell-independent antigens such as lipopolysaccharide (LPS), trinitrophenylated (TNP)-LPS and TNP-Ficoll. The pattern of HAA-mediated immunopotentiation was similar to that of dibutyryl… Expand
2 Citations
Effects of heptaminol AMP amidate on suppressor and helper function of murine T cells.
TLDR
The present results suggested that HAA-mediated immunopotentiation was possible by a combined suppressive effect on Ts cells and enhancing effect on Th cells. Expand
Effects of heptaminol AMP amidate (HAA) on cyclic AMP level and mitogen-induced proliferation of murine spleen cells.
TLDR
The present results supported the previous findings that HAA-mediated immunopotentiation was closely related with a cAMP level elevating property of HAA, and the compound also enhanced the function of helper T cells. Expand

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