Effect of hepatocyte growth factor on the proliferation of intrasplenically transplanted hepatocytes in rats.

Abstract

The effect of human hepatocyte growth factor on the proliferation of intrasplenically transplanted hepatocytes was investigated. A human hepatocyte growth factor (360 micrograms/kg BW) was administered intravenously every 24 hr for 5 days following hepatocyte transplantation in rats. A significant increase in hepatocyte proliferation was observed morphologically and immunohistochemically (p < 0.05). The bromodexyuridine labeling index was significantly greater in human hepatocyte growth factor treated rats than in the control rats (p < 0.05). Hepatocyte growth factor may promote the proliferation of intrasplenically transplanted hepatocytes.

Cite this paper

@article{Kato1996EffectOH, title={Effect of hepatocyte growth factor on the proliferation of intrasplenically transplanted hepatocytes in rats.}, author={Kentaro Kato and Kenji Onodera and Miki Sawa and Manami Imai and Toshiyasu Kawahara and Shinichi Kasai and Michio Mito}, journal={Biochemical and biophysical research communications}, year={1996}, volume={222 1}, pages={101-6} }