Effect of hepatitis C and B virus infection on risk of hepatocellular carcinoma: a prospective study.

@article{Tsai1997EffectOH,
  title={Effect of hepatitis C and B virus infection on risk of hepatocellular carcinoma: a prospective study.},
  author={J. F. Tsai and J. E. Jeng and Michael Shiu-Yan Fremont Ho and William Y.C. Chang and Ming Yu Hsieh and Zhunxiang Lin and Ju- He Tsai},
  journal={British Journal of Cancer},
  year={1997},
  volume={76},
  pages={968 - 974}
}
To assess whether there is an additive effect between chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infection on the development of hepatocellular carcinoma (HCC), 400 consecutive cirrhotic patients were followed prospectively with periodic abdominal ultrasound examination and measurement of serum alpha-fetoprotein (AFP) level every 4 months. During a follow-up of 1185 person-years, 80 (20%) patients developed HCC, with an annual incidence of 6.8%. The annual incidence was 2.0% in… CONTINUE READING
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