Effect of hepatic lipase -514C->T polymorphism and its interactions with apolipoprotein C3 -482C->T and apolipoprotein E exon 4 polymorphisms on the risk of nephropathy in chinese type 2 diabetic patients.

@article{Baum2005EffectOH,
  title={Effect of hepatic lipase -514C->T polymorphism and its interactions with apolipoprotein C3 -482C->T and apolipoprotein E exon 4 polymorphisms on the risk of nephropathy in chinese type 2 diabetic patients.},
  author={Larry Baum and Maggie C Y Ng and Wing-Yee So and Vincent K L Lam and Ying Wang and Emily W M Poon and Brian Tomlinson and Suzanne Cheng and Klaus Lindpaintner and Juliana C. N. Chan},
  journal={Diabetes care},
  year={2005},
  volume={28 7},
  pages={
          1704-9
        }
}
OBJECTIVE Triglyceride-rich lipoprotein particles may promote the progression of diabetic nephropathy. Patients with diabetic nephropathy have increased plasma triglycerides and reduced activity of hepatic lipase (HL), which hydrolyzes triglycerides. We hypothesized that the HL -514C-->T polymorphism, which reduces HL expression, and its interactions with polymorphisms in apolipoprotein (apo) E and apoC3 increase the risk of diabetic nephropathy. RESEARCH DESIGN AND METHODS In a case-control… CONTINUE READING
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