Effect of hepatic CYP inhibitors on the metabolism of sildenafil and formation of its metabolite, N-desmethylsildenafil, in rats in vitro and in vivo.

@article{Bae2009EffectOH,
  title={Effect of hepatic CYP inhibitors on the metabolism of sildenafil and formation of its metabolite, N-desmethylsildenafil, in rats in vitro and in vivo.},
  author={Soo Hyeon Bae and Myung Gull Lee},
  journal={The Journal of pharmacy and pharmacology},
  year={2009},
  volume={61 12},
  pages={1637-42}
}
OBJECTIVES It has been reported that hepatic cytochrome P450 (CYP)2C9 and CYP3A4 are responsible for the metabolism of sildenafil and formation of its metabolite, N-desmethylsildenafil, in humans. However, in-vivo studies in rats have not been reported. METHODS Sildenafil (20 mg/kg) was administered intravenously to rats pretreated with sulfaphenazole… CONTINUE READING