Effect of heparin on pulmonary fibroblasts and vascular cells.

@article{Yamashita1992EffectOH,
  title={Effect of heparin on pulmonary fibroblasts and vascular cells.},
  author={Yukiko M Yamashita and Kazuya Nakagomi and Takahisa Takeda and Shunji Hasegawa and Youji Mitsui},
  journal={Thorax},
  year={1992},
  volume={47 8},
  pages={
          634-9
        }
}
BACKGROUND There is a large increase in mast cell numbers in fibrotic lung tissue, suggesting that mast cells may play a part in the pathogenesis of pulmonary fibrosis. Glycosaminoglycans, such as heparan sulphate, that are structurally related to heparin (a mast cell product) are part of the extracellular matrix and known to regulate cell growth. Basic fibroblast growth factor is a heparin binding growth factor produced by endothelial cells. METHODS A study was carried out to examine the… CONTINUE READING

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