Effect of heparin on conformation of the β2-microglobulin molecule.

@article{Uji2012EffectOH,
  title={Effect of heparin on conformation of the β2-microglobulin molecule.},
  author={Yoshinori Uji and Yoshihiro Motomiya and Yukio Ando},
  journal={Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy},
  year={2012},
  volume={16 2},
  pages={159-62}
}
Heparin, one of the essential molecules called glycosaminoglycans (GAGs), is the anticoagulant that is commonly used in regular hemodialysis, during which dialysis-related amyloidosis (DRA) may develop. The pathogenic protein, i.e. precursor protein, in DRA is β(2)-microglobulin (β(2)m). Recent studies defined amyloidosis as a protein misfolding disease of… CONTINUE READING