Effect of hemodialysis on hepatic cytochrome P450 functional expression.

  title={Effect of hemodialysis on hepatic cytochrome P450 functional expression.},
  author={Jos{\'e}e Michaud and Thomas D Nolin and Judith Naud and M{\'e}lina Dani and Jean-Philippe Lafrance and François A. Leblond and Jonathan Himmelfarb and Vincent Pichette},
  journal={Journal of pharmacological sciences},
  volume={108 2},
Cytochrome P450 (CYP) functional expression is reduced in uremia and normalized after restoration of kidney function via transplantation. The aim of this study was to evaluate the effect of conventional hemodialysis on the functional expression of CYP1A, 2C, and 3A. We also investigated the role of nuclear factor-kappaB (NF-kappaB) in CYP regulation during uremia. Primary cultures of normal rat hepatocytes were incubated with serum obtained from end-stage renal disease patients pre- and post… CONTINUE READING

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