Effect of heat shock preconditioning on NF-kappaB/I-kappaB pathway during I/R injury of the rat liver.

@article{Uchinami2002EffectOH,
  title={Effect of heat shock preconditioning on NF-kappaB/I-kappaB pathway during I/R injury of the rat liver.},
  author={Hiroshi Uchinami and Yuzo Yamamoto and Makoto Kume and Kei Yonezawa and Yasuhide Ishikawa and Kojiro Taura and Akio Nakajima and Koichiro Hata and Yoshio Yamaoka},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2002},
  volume={282 6},
  pages={G962-71}
}
Hepatic ischemia-reperfusion (I/R) injury continues to be a fatal complication after liver surgery. Heat shock (HS) preconditioning is an effective strategy for protecting the liver from I/R injury, but its exact mechanism is still unclear. Because the activation of nuclear factor-kappaB (NF-kappaB) is an important event in the hepatic I/R-induced inflammatory response, the effect of HS preconditioning on the pathway for NF-kappaB activation was investigated. In the control group, NF-kappaB was… CONTINUE READING

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